Here you will find corporate news and information about new products, applications and projects.
The new CellCelector
™ Flex is now on the market
The next generation of the ALS CellCelector
™, the CellCelector ™ Flex, offers many new and improved features that open up new application fields for the user and even further simplifies the process of cell identification and isolation.
The completely new microscope optics has been fully automated. Changing between objectives, switching from bright field to phase contrast or fluorescence as well as switching between different fluorescence colors is now entirely software-controlled. The image quality, in particular of the fluorescence images, was once again significantly improved.
The new motorized stage is characterized by an even higher precision leading to unrivaled stitching accuracy and ensuring best possible screening and picking results. The new hardware design makes changing samples easier than ever. Finally the speed of the entire scanning and picking process has been significantly increased.
Contact us for more information about the new CellCelector
October 01, 2020
Next-generation nanowell array available now:
Capture, detect and recover single cells in SIEVEWELL
™ without cell loss
We are pleased to introduce TOK SIEVEWELL
™, a next-generation nanowell array for rare single cell isolation approaches.
The key component of SIEVEWELL™ is a thin membrane with nanowell structures fabricated by photolithography. On an area of 17 mm x 17 mm, 370,000 nanowells with dimensions of 20 µm x 25 µm (width x depth) can be found.
Each nanowell connects the fluid volume above and below it by two 2 µm pores at its bottom. This pore size is suitable for fluid exchange but will prevent cell passage. The fluid volume below the nanowells is connected to two side ports by a micro gap. Through this a one-directional fluid flow from the inner chamber holding the cells to the side ports can be generated by aspiration with a pipette at the side ports.
Applying a biological sample cells will follow the liquid flow and are trapped in the nanowells. As each cell partially blocks the pores and therefore reduces liquid flow through the corresponding nanowell upon entering the next cell will be drawn in another nanowell resulting in a self-sorting single cell capture. Following cell loading on-chip staining can be performed without any cell loss during fixation, permeabilization, blocking, incubation and washing. As such the device is highly suitable for staining of rare cells like circulating tumor cells, fetal cells etc.
SIEVEWELL™ with 20 µm nanowells with 2 pores
The SIEVEWELL™ membrane is characterized by high transparency during bright field microscopy as well as very low auto-fluorescence allowing for acquisition of high-quality microscopic imaging data. The chip size supports fast, automated scanning of the cell capture area and identified target cells can be specifically retrieved at single cell level in 100% purity using the ALS CellCelector™ technology.
Contact us for more information about the new SIEVEWELL™ chips.
Odering information can be found under Nanowell arrays.
July 03, 2020
Start of the new project: "Development and validation of a high-throughput process for single cell cloning of genetically modified mammalian cells for the production of biopharmaceutically applicable production cell lines using a novel technology platform"
Term: July 03, 2020 to December 31, 2022
The project is funded by the European Union's European Regional Development Fund and by the State of Thuringia.
December 12, 2019
We have a new website
Thanks to our new, modern and user-friendly website, you can now contact us even more easily. In addition to the proven options via e-mail, telephone and fax, you can also send us your requests, wishes or enquiries quickly and in detail using special contact forms. The corresponding experts will contact you immediately.
Information about our products and services you can find now easier and faster. Under Products you can find information about the CellCelector, our safety cabinets and flow boxes, the consumables required for the CellCelector and individual components such as precision axes or motorised stages.
You will find the most important applications of the CellCelector in the chapter Applications, which are sorted here according to the different research fields.
Publications, brochures and videos about our devices can be found under Resources. You can also find answers to frequently asked questions under FAQ.
We hope you enjoy our new website. Have fun browsing. We are looking forward to your feedback.